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KMID : 0377219990240020048
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Medical Journal of Chosun Univercity
1999 Volume.24 No. 2 p.48 ~ p.55
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A Role of DCC protein as a prognosticator in colorectal cancer
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Lee Man-Jae
Yu Ki-Dong
Shon Hyun-Hwa
Jung Jae-Yung
Kim Yang-Soo
Kim Tae-Goon
Suh Young-Seon
Park Yoo-Hwan
Chung Choon-Hae
Lee Mi-Ja
Park Jong
Oh Yoon-Kyeong
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Abstract
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Purpose: Even though the entire resection is only option for primary cure in case of the localized colorectal cancer. However, recurrence rate is relatively high(30%). The evaluation for chromosome 18 long arm status in the patients who have stage II colon cancer gives a important information about a prognosis and evaluation of the patients. This study was undertaken to evaluate the possible prognostic role of the expression of deleted in colorectal cancer (DCC) protein in the patients with stage II colon cancer.
Materials and Methods: The present study analysed 22 patients with stage II &II (AJC TNM 1992 classification) colorectal adenocarcinoma who were admitted to the Chosun University Hospital between March 1989 and February 1992. Clinicopathologic parameters including age, sex, TNM stage, adjuvant chemotherapy, location and tumor differentiation and DCC status were examined.
Results: The survival rate of the patients expressing DCC was found to be significantly higher in the patients in whom the DCC was expressed, while 4 (18%) in the other who had not the expression of DCC(P= 0.044). Although the patients with the stage II of the TNM stage have a better prognosis than those with stage III (P=0.046), no significant difference was found between these two groups in terms of the eastern cooperative oncology group (ECOG) performance status of patients (P= 0.525).
Conclusion: when the expression of DCC protein is negative in patients with colon cancer staged II need a more aggressive treatments like in the patients with staged III colon cancer and thereafter the more exact operative method is required identifying the expression of DCC protein using the frozen biopsy during operation and thereafter the consideration for the chemotherapy and radiation therapy will be possible.
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KEYWORD
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DCC protein, Colorectal carcinoma, Prognosis
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